Nature and incidence of severe limbal stem cell deficiency in Australia and New Zealand
Nature and incidence of severe limbal stem cell deficiency in Australia and New Zealand
复制标题
DOI：
10.1111/ceo.12813
复制
发表时间：
2017-03-01
影响因子：
4
通讯作者：
Watson, Stephanie
中科院分区：
文献类型：
--
作者：
Bobba, Samantha;Di Girolamo, Nick;Watson, Stephanie
背景资料：本研究旨在确定严重角膜缘干细胞缺乏症（LSCD）在澳大利亚和新西兰的性质和发病率。设计：一项为期1年的试点监测研究与1年的随访期进行了与澳大利亚和新西兰眼科监测单位。参与者：这项研究包括患者报告的执业眼科医生对监测单位的数据库。方法：向眼科医生提供严重角膜缘干细胞缺乏症的定义，该单位每月联系眼科医生，并要求他们报告新诊断的病例。重度LSCD定义为至少6个小时的螺旋状上皮病变，即从利姆布斯产生的不透明上皮，受累上皮和浅层角膜新生血管或结膜的晚期荧光素染色。结果：平均而言，监察组每月向执业眼科医生发出286份报告卡（12个月共3 429份），该股平均每月收到176份答复（共2 111份;答复率为62%）。在2013年4月至2014年3月的一年研究期间，向该股报告了14例阳性病例。一系列的潜在病因有牵连，接触透镜过度磨损和愈合结膜炎是最常见的（n = 3）。结论：这项监测研究是第一个世界范围内记录角膜缘干细胞缺乏症的发病率，但是，由于研究设计的局限性，它很可能已被低估。它提供了治疗眼科医生报告的角膜缘干细胞缺乏症患者的人口统计学、临床状况和管理的新数据。
Background: This study aimed to determine the nature and incidence of severe limbal stem cell deficiency (LSCD) in Australia and New Zealand.Design: A 1-year pilot surveillance study with a 1-year follow-up period was conducted in association with the Australian and New Zealand Ophthalmic Surveillance Unit.Participants: The study included patients reported by practising ophthalmologists on the Surveillance Unit's database.Methods: Ophthalmologists were provided with a definition of severe limbal stem cell deficiency, contacted on a monthly basis by the Unit and asked to report newly diagnosed cases.Main Outcome Measures: Severe LSCD was defined as at least 6 clock hours of whorl-like epitheliopathy, an opaque epithelium arising from the limbus, late fluorescein staining of the involved epithelium and superficial corneal neovascularization or conjunctivalization.Results: On average, 286 report cards were sent by the Surveillance Unit to practising ophthalmologists each month (total 3429 over 12 months) and the Unit received an average of 176 responses per month (total 2111; 62% response rate). During the 1-year study period from April 2013 to March 2014, 14 positive cases were reported to the Unit. A range of underlying aetiologies were implicated, with contact lens over-wear and cicatrizing conjunctivitis being the most common (n = 3).Conclusions: This surveillance study is the first worldwide to document the incidence of limbal stem cell deficiency; however, because of study design limitations, it is likely to have been under-reported. It provides novel data on the demographics, clinical conditions and management of patients with limbal stem cell deficiency as reported by treating ophthalmologists.