Clinical Characteristics of Keratitis Due to Colletotrichum gloeosporioides
Clinical Characteristics of Keratitis Due to Colletotrichum gloeosporioides
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DOI：
10.1089/jop.2011.0011
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发表时间：
2011-10-01
影响因子：
2.3
通讯作者：
Ohashi, Yuichi
中科院分区：
文献类型：
--
作者：
Shiraishi, Atsushi;Araki-Sasaki, Kaoru;Ohashi, Yuichi
目的：探讨胶孢炭疽菌引起的角膜炎的特点。方法：回顾性分析3例胶孢炭疽菌引起的真菌性角膜炎的病历，明确其临床特点。测定了所有 3 种分离株的不同抗真菌药物的最低抑菌浓度。所有 3 个分离株均在 25°C、35°C 和 37°C 的沙氏葡萄糖琼脂上生长，以确定温度敏感性生长。结果：所有 3 名患者均居住在日本西南部，并患有涉及有机物质的眼外伤。感染灶位于前基质中，并且在所有病例中都没有深入到基质中。角膜炎采用抗真菌药物治疗，包括外用伏立康唑和那他霉素眼膏，并在 2-3 周内得到缓解。所有分离的菌株在 25°C 下生长良好，但在 35°C 和 37°C 下生长较差。所有分离的菌株具有相似的药物敏感性特征；对两性霉素B、伊曲康唑、咪康唑、米卡芬净、伏立康唑敏感，对氟胞嘧啶、氟康唑、那他霉素相对耐药。结论：3例胶孢梭菌角膜炎临床特征相似。药物敏感性特征的相似性应该有助于治疗胶孢梭菌角膜炎。
Purpose: To determine the characteristics of the keratitis due to Colletotrichum gloeosporioides.Methods: The medical records of 3 cases of fungal keratitis caused by C. gloeosporioides were reviewed to determine the clinical characteristics. The minimal inhibitory concentrations of different antifungal drugs for all 3 isolates were determined. All 3 isolates were grown on Sabouraud dextrose agar at 25 degrees C, 35 degrees C, and 37 degrees C to determine the temperature-sensitive growth.Results: All 3 patients lived in the southwestern part of Japan and had an ocular trauma involving organic materials. The infectious foci were localized in the anterior stroma, and they did not extend deep into the stroma in all cases. The keratitis was treated with antifungal medications including topical voriconazole and natamycin eye ointment, and was resolved in 2-3 weeks. All of the isolated strains grew well at 25 degrees C but poorly at 35 degrees C and 37 degrees C. All isolated strains had similar drug-sensitivity profiles; they were sensitive to amphotericin B, itraconazole, miconazole, micafungin, and voriconazole, and relatively resistant to flucytosine, fluconazole, and natamycin.Conclusions: All 3 cases of C. gloeosporioides keratitis had similar clinical features. The similarities in the drug-sensitivity profiles should be helpful in treating C. gloeosporioides keratitis.