Functional polymers of gene delivery for treatment of myocardial infarct.
Functional polymers of gene delivery for treatment of myocardial infarct.
复制标题
DOI：
10.1016/j.jconrel.2014.07.041
复制
发表时间：
2014-12-10
期刊：
影响因子：
--
通讯作者：
Kim SW
中科院分区：
文献类型：
--
作者：
Won YW;Bull DA;Kim SW
缺血性心脏病正迅速成为世界上常见的死亡原因。它是一种由于冠状动脉狭窄而发生的疾病，是由于氧气供应和需求之间的不平衡导致心肌缺氧而引起的。传统的药物治疗主要集中在药物洗脱支架的应用、冠状动脉旁路移植术和抗血栓治疗。基因治疗为心血管疾病的治疗提供了巨大的机会。为了使基因治疗获得成功，开发合适的基因递送系统和低氧调节的基因表达载体是最重要的因素。已经开发了几种非病毒基因转移方法来克服病毒转导的安全性问题。其中一些包括调节基因表达的质粒，所述基因表达在转录或翻译水平上由环境特异性启动子控制。本文综述了靶向心肌的多聚体基因载体和缺氧诱导型基因表达载体及其在心肌梗死动物模型中的应用。
Ischemic heart disease is rapidly growing as the common cause of death in the world. It is a disease that occurs as a result of coronary artery stenosis and is caused by the lack of oxygen within cardiac muscles due to an imbalance between oxygen supply and demand. The conventional medical therapy is focused on the use of drug eluting stents, coronary-artery bypass graft surgery and anti-thrombosis. Gene therapy provides great opportunities for treatment of cardiovascular disease. In order for gene therapy to be successful, the development of proper gene delivery systems and hypoxia-regulated gene expression vectors are the most important factors. Several non-viral gene transfer methods have been developed to overcome the safety problems of viral transduction. Some of which include plasmids that regulate gene expression that is controlled by environment specific promoters in the transcriptional or the translational level. This review explores polymeric gene carriers that target the myocardium and hypoxia-inducible vectors, which regulate gene expression in response to hypoxia, and their application in animal myocardial infarction models.
登录
查看更多内容
影响因子：
10.8
作者：
Ahn, CH;Chae, SY;Kim, SW
通讯作者：
Kim, SW
影响因子：
10.8
作者：
Chang, Chien-Wen;Christensen, Lane V.;Kim, Sung Wan
通讯作者：
Kim, Sung Wan
影响因子：
4.5
作者：
Benns, JM;Maheshwari, A;Kim, SW
通讯作者：
Kim, SW
影响因子：
10.8
作者：
Bull, DA;Bailey, SH;Kim, SW
通讯作者：
Kim, SW
影响因子：
4.7
作者：
Christensen, Lane V.;Chang, Chien-Wen;Feijen, Jan
通讯作者：
Feijen, Jan