Form and function of archaeal genomes.
Form and function of archaeal genomes.
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DOI：
10.1042/bst20221396
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发表时间：
2022-12-16
影响因子：
3.9
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中科院分区：
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现代主义建筑的一个关键格言是“形式服从功能”。虽然现代主义建筑物是智能设计的产物，但染色体的结构是由数千代进化的力量塑造的。在下文中，我将描述我们对生命古菌领域染色体结构的理解的最新进展。尽管关于古细菌染色体组织的机械细节还有很多东西有待了解，但一些普遍的原则已经出现。在10-100 kb的水平上，古细菌染色体有一个保守的局部组织，让人想起细菌基因组。 相比之下，特定血统的创新似乎强加了独特的大规模建筑特征。基因组的最终功能是储存和表达遗传信息。基因表达谱已被证明影响染色体结构，因此它们的形式遵循功能。然而，染色体构象的局部变化也会影响基因表达，因此，在这些情况下，功能遵循形式。
A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe recent advances in our understanding of chromosome architecture in the archaeal domain of life. Although much remains to be learned about the mechanistic details of archaeal chromosome organization, some general principles have emerged. At the 10–100 kb level, archaeal chromosomes have a conserved local organization reminiscent of bacterial genomes. In contrast, lineage-specific innovations appear to have imposed distinct large-scale architectural features. The ultimate functions of genomes are to store and to express genetic information. Gene expression profiles have been shown to influence chromosome architecture, thus their form follows function. However, local changes to chromosome conformation can also influence gene expression and therefore, in these instances, function follows form.