New twist in the regulation of cyclin D1.
New twist in the regulation of cyclin D1.
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DOI：
10.1515/bmc.2010.029
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Yoneda-Kato, Noriko
中科院分区：
文献类型：
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作者：
Kato, Jun-Ya;Yoneda-Kato, Noriko
在与细胞周期相关的哺乳动物细胞周期蛋白中，细胞周期蛋白D1比细胞周期时钟本身与细胞增殖响应细胞外信号的关系更密切。因为它的mRNA和蛋白质都是不稳定的，细胞周期蛋白D1的细胞内丰度被认为在很大程度上是在转录水平上调节的。然而，最近的研究结果表明，在某些类型的细胞中，细胞周期蛋白D1是后炎症调节，这种调节机制的干扰诱导异常进入细胞周期和增殖，有时导致疾病，如癌症。在这篇综述中，我们总结了最近的研究结果和讨论的生理作用和细胞功能的新机制，调节细胞周期蛋白D1在控制细胞增殖。
Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of transcription. However, recent findings suggest that, in certain cell types, cyclin D1 is post-translationally regulated, and a disturbance of this regulatory mechanism induces aberrant entry into the cell cycle and proliferation, sometimes leading to diseases such as cancer. In this review, we summarize recent findings and discuss the physiological role and cellular function of the novel mechanism of regulation of cyclin D1 in terms of the control of cell proliferation.