Plasma thrombin-antithrombin III complex is associated with the severity of experimental autoimmune encephalomyelitis
Plasma thrombin-antithrombin III complex is associated with the severity of experimental autoimmune encephalomyelitis
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DOI：
10.1016/s0022-510x(01)00468-3
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发表时间：
2001-04-01
影响因子：
4.4
通讯作者：
Koh, CS
中科院分区：
文献类型：
--
作者：
Inaba, Y;Ichikawa, M;Koh, CS
先前的研究表明，在患有实验性自身免疫性脑脊髓炎（EAE）的动物中观察到血液凝固的激活和CNS血管周围的纤维蛋白沉积，这为人类自身免疫性脱髓鞘疾病提供了动物模型。我们检测了刘易斯大鼠EAE外周血纤维蛋白原、凝血酶-抗凝血酶Ⅲ复合物（达特）、纤溶活性和纤维蛋白降解产物的含量，以阐明血液凝固-纤溶系统在EAE中的作用。血浆达特值在症状出现前即刻升高，并随症状改善而降低。达特值与EAE临床评分有显著相关性，其他指标与EAE症状无相关性。这些结果表明，血浆达特水平是EAE严重程度的敏感标志物，并且可能是人类自身免疫性脱髓鞘疾病严重程度的有用临床指标。(C)2001 Elsevier science B. V.保留所有权利。
Previous studies have shown that activation of blood coagulation and fibrin depositions around CNS vessels are observed in animals with experimental autoimmune encephalomyelitis (EAE), which provides an animal model for human autoimmune demyelinating disorders. We examined the values of peripheral blood fibrinogen, thrombin-antithrombin III complex (TAT), fibrinolytic activity, and fibrin degradation products in Lewis rats with EAE to elucidate the role of the blood coagulation-fibrinolysis system in EAE. Plasma TAT values increased immediately prior to development of symptoms, and decreased according to the improvement of symptoms. There was significant correlation between TAT values and clinical scores of EAE: other markers were not correlated with the symptoms of EAE. These results suggest that plasma TAT levels are sensitive markers of the severity of EAE, and may he useful clinical indicators for the severity of human autoimmune demyelinating disorders. (C) 2001 Elsevier science B.V. All rights reserved.