Targeting the host inflammatory response in traumatic spinal cord injury
Targeting the host inflammatory response in traumatic spinal cord injury
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DOI：
10.1097/00019052-200206000-00021
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发表时间：
2002-06-01
影响因子：
4.8
通讯作者：
Dietrich, WD
中科院分区：
文献类型：
--
作者：
Bethea, JR;Dietrich, WD
在脊髓损伤的实验模型中，急性和慢性炎症过程都显示出影响结果。虽然早期炎症反应可能参与继发性损伤过程，但更多的延迟炎症事件可能是修复性的。靶向这些事件的治疗策略目前基于已经阐明了对损伤的炎症反应中涉及的细胞和分子过程的实验发现。越来越多的文献支持这样的假设，即治疗性低温和其他抗炎策略减弱了急性炎症事件，而免疫神经保护和轴突再生可以通过转移活化的T细胞或通过用治疗性疫苗治疗来实现。这些数据在本审查中进行了总结。
Both acute and chronic inflammatory processes have been shown to influence outcome in experimental models of spinal cord injury. Although early inflammatory responses may participate in secondary injury processes, more delayed inflammatory events may be reparative. Therapeutic strategies that target these events are currently based on experimental findings that have clarified the cellular and molecular processes involved in the inflammatory response to injury, An increasing body of literature supports the hypothesis that acute inflammatory events are attenuated by therapeutic hypothermia and other anti-inflammatory strategies, whereas immune neuroprotection and axonal regeneration can be achieved by transfer of activated T cells or by treatment with therapeutic vaccines. These data are summarized in the present review.