On the formalization of multi-scale and multi-science processes for integrative biology
On the formalization of multi-scale and multi-science processes for integrative biology
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DOI：
10.1098/rsfs.2010.0038
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发表时间：
2011-06-06
期刊：
影响因子：
4.4
通讯作者：
Pichardo-Almarza, Cesar
中科院分区：
文献类型：
--
作者：
Diaz-Zuccarini, Vanessa;Pichardo-Almarza, Cesar
这项工作的目的是介绍在多物理场和多尺度过程背景下应用的“键图”（BG）技术的一般概念。BG建模在这些发展中自然占有一席之地。bg本质上是一致的，因为图中“元素”之间的关系是由因果规则和能量守恒严格定义的。BGs清楚地显示了它们所代表的系统组件之间的功率流动。“努力”和“流量”变量在BG模型中实现了双向信息流。当系统的功率水平较低时，bg退化为信号流图，其中信息主要是一维的，功率最小，也就是说，当处理个体群体或纯动力学模型时，它们会发现一个自然的限制，因为这些系统中的能量守恒概念不再相关。这项工作的目的是双重的：一方面，我们将介绍在多科学和多尺度模型背景下应用的BG技术的一般概念；另一方面，我们将通过与使用成熟的建模技术/软件开发的示例进行比较，突出BG方法中一些最有前途的特征，这些示例可以从结构和能量的角度提供一致的框架，从而建议对当前最先进的工具进行开发或改进。
The aim of this work is to introduce the general concept of 'Bond Graph' (BG) techniques applied in the context of multi-physics and multi-scale processes. BG modelling has a natural place in these developments. BGs are inherently coherent as the relationships defined between the 'elements' of the graph are strictly defined by causality rules and power (energy) conservation. BGs clearly show how power flows between components of the systems they represent. The 'effort' and 'flow' variables enable bidirectional information flow in the BG model. When the power level of a system is low, BGs degenerate into signal flow graphs in which information is mainly one-dimensional and power is minimal, i.e. they find a natural limitation when dealing with populations of individuals or purely kinetic models, as the concept of energy conservation in these systems is no longer relevant. The aim of this work is twofold: on the one hand, we will introduce the general concept of BG techniques applied in the context of multi-science and multi-scale models and, on the other hand, we will highlight some of the most promising features in the BG methodology by comparing with examples developed using well-established modelling techniques/software that could suggest developments or refinements to the current state-of-the-art tools, by providing a consistent framework from a structural and energetic point of view.