DIMINISHED BRAIN GLUCOSE-METABOLISM IS A SIGNIFICANT DETERMINANT FAR FALLING RATES OF SYSTEMIC GLUCOSE-UTILIZATION DURING SLEEP IN NORMAL HUMANS
DIMINISHED BRAIN GLUCOSE-METABOLISM IS A SIGNIFICANT DETERMINANT FAR FALLING RATES OF SYSTEMIC GLUCOSE-UTILIZATION DURING SLEEP IN NORMAL HUMANS
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DOI：
10.1172/jci117003
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发表时间：
1994-02-01
影响因子：
15.9
通讯作者：
HOFFMAN, C
中科院分区：
文献类型：
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作者：
BOYLE, PJ;SCOTT, JC;HOFFMAN, C
人类睡眠期间全身葡萄糖利用率下降。我们测试了这一假设，即使用率的下降在很大程度上是由大脑葡萄糖代谢减少造成的。10名正常受试者行颈内动脉和桡动脉插管，用N2O平衡技术测定脑血流量，并定量测定睡前和睡眠中每隔3h的跨脑血糖和血氧差。用连续脑电图法对睡眠分期进行分级，用同位素稀释法测定全身糖代谢。脑葡萄糖代谢从睡前(2300h)的33.6+/-2.2mMol/100g/min(平均+/-SE)下降到睡眠中0300h的平均最低值24.3+/-1.1mMol/100g/min(P=0.001)。相应的全身性葡萄糖利用速率由13.2+/-0.8降至11.0+/-0.5Mol/kg/min(P=0.003)。脑葡萄糖代谢减弱的原因是动静脉血糖差从0.643+/-0.024降至0.546+/-0.020 mmoL/L(P=0.002)，脑血流量由50.3+/-2.8cc/100g/min降至44.6cc/100g/min(P=0.021)。脑氧代谢由153.4±11.8U/min降至128.0+/-8.4U/100g/min(P=0.045)。观察到的脑代谢减少与中枢神经系统电活动(脑电数据)的阶段无关，与睡眠时间更密切相关。我们的结论是，大脑葡萄糖代谢的下降是睡眠期间全身葡萄糖利用率下降的一个重要决定因素。
Systemic glucose utilization declines during sleep in man. We tested the hypothesis that this decline in utilization is largely accounted for by reduced brain glucose metabolism. 10 normal subjects underwent internal jugular and radial artery cannulation to determine cerebral blood flow by N2O equilibrium technique and to quantitate cross-brain glucose and oxygen differences before and every 3 h during sleep. Sleep stage was graded by continuous electroencephalogram, and systemic glucose turnover was estimated by isotope dilution. Brain glucose metabolism fell from 33.6 +/- 2.2 mu mol/100 g per min (mean +/- SE) before sleep (2300 h) to a mean nadir of 24.3 +/- 1.1 mu mol/100 g per min at 0300 h during sleep (P = 0.001). Corresponding rates of systemic glucose utilization fell from 13.2 +/- 0.8 to 11.0 +/- 0.5 mu mol/kg per min (P = 0.003). Diminished brain glucose metabolism was the product of a reduced arteriovenous glucose difference, 0.643 +/- 0.024 to 0.546 +/- 0.020 mmol/liter (P = 0.002), and cerebral blood flow, 50.3 +/- 2.8 to 44.6 +/- 1.4 cc/100 g per min (P = 0.021). Brain oxygen metabolism fell commensurately from 153.4 +/- 11.8 to 128.0 +/- 8.4 mu mol/100 g per min (P = 0.045). The observed reduction in brain metabolism occurred independent of stage of central nervous system electrical activity (electroencephalographic data), and was more closely linked to duration of sleep. We conclude that a decline in brain glucose metabolism is a significant determinant of falling rates of systemic glucose utilization during sleep.