EGF-Related Peptides and Their Receptors in Mammary Gland Development
EGF-Related Peptides and Their Receptors in Mammary Gland Development
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DOI：
10.1023/a:1026395513038
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发表时间：
1997-04-01
影响因子：
2.5
通讯作者：
Sebastian, Joseph
中科院分区：
文献类型：
--
作者：
DiAugustine, Richard P.;Richards, R. Gregg;Sebastian, Joseph
多种EGF样配体和erbB受体的发现为高度多样化的信号传导系统提供了可能性，该信号传导系统允许特异性配体/受体复合物响应于特定激素或乳腺发育阶段而产生。已知的erbB受体和几种erbB相关配体由正常乳腺合成，并且具有不同的时间和空间表达模式。例如，累积的研究结果支持这样的概念，即EGF受体在乳腺的形态发生中具有重要作用，并且该受体的激活响应于乳腺基质细胞中EGF受体配体的雌二醇刺激合成而发生。在这篇综述中强调了上皮和基质乳腺细胞在erbB相关通路的激素激活中的重要性。目前的实验方案，利用erbB突变小鼠或使检测磷酸化erbB成员和他们的近端底物应允许更精确的识别乳腺中的工作途径。
The discovery of multiple EGF-like ligands and erbB receptors offers the potential for a highly diverse signaling system allowing specific ligand/receptor complexes to be created in response to a certain hormone(s) or stage of mammary development. The known erbB receptors and several of the erbB-related ligands are synthesized by the normal mammary gland and have different temporal and spatial expression patterns. For instance, cumulative findings support the concepts that the EGF receptor has an essential role in morphogenesis of the mammary gland and that activation of this receptor occurs in response to estradiol-stimulated synthesis of an EGF receptor ligand in mammary stromal cells. The importance of both epithelial and stromal mammary cells in the hormonal activation of erbB-related pathways is underscored in this review. Current experimental protocols that utilize erbB mutant mice or enable detection of phosphorylated erbB members and their proximal substrates should permit more precise identification of the pathways operative in the mammary gland.