Pre-pregnancy dietary arsenic consumption among women in the United States.
Pre-pregnancy dietary arsenic consumption among women in the United States.
复制标题
美国女性孕前膳食砷摄入量。
DOI：
10.1002/bdr2.1634
复制
发表时间：
2020
影响因子：
2.1
通讯作者：
NationalBirthDefectsPreventionStudy
中科院分区：
文献类型：
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作者：
Suhl,Jonathan;Conway,KristinM;Rhoads,Anthony;Langlois,PeterH;Feldkamp,MarciaL;Michalski,Adrian;Romitti,PaulA;NationalBirthDefectsPreventionStudy
背景砷中毒与多种不良健康结局有关，包括一些出生缺陷。虽然饮食是美国砷暴露的主要途径，但关于美国女性孕前饮食砷摄入量的数据有限。方法利用国家出生缺陷预防研究(NBDPS)收集的数据，我们估计了1997-2011年出生的10,886名非畸形对照儿童的母亲孕前一年的饮食砷摄入量。对NBDPS膳食评估的反应以及对总砷和无机砷的食物项目估计被用来估计消费量。结果孕妇总砷摄入量为14.9μg/d，膳食无机砷摄入量为5.2 mgg/d。观察到几个与排除零值的置信度区间正相关和负相关。比较中或高总砷摄入量的母亲和低三分位数的母亲，我们观察到母亲的年龄(≥30 年)、较低(0-8 年)或更高(>；12 年)教育、种族/民族(非西班牙裔黑人、西班牙裔等)和怀孕早期饮酒没有暴饮暴食的正相关(优势比=1.33.8)，以及与年龄(<；25 年)、体重指数(≥30.0 kg/m2)和怀孕早期吸烟的负相关(优势比=0.40.8)。结论这些对美国女性孕前膳食砷摄入量的当代估计表明，总膳食砷摄入量和无机膳食砷摄入量与几个母亲特征之间存在关联，从而改善了这种暴露对公共健康影响的表征。
BackgroundArsenic is associated with several adverse health outcomes, including some birth defects. Although diet is the predominant route of arsenic exposure in the United States (U.S.), limited data exist regarding pre‐pregnancy dietary arsenic consumption among U.S. women.MethodsUsing data collected in the National Birth Defects Prevention Study (NBDPS), we estimated daily dietary arsenic consumption during the year before pregnancy for 10,886 mothers of nonmalformed control children delivered from 1997–2011. Responses to the NBDPS dietary assessment and food item estimates of total and inorganic arsenic were used to estimate consumption. Associations between total and inorganic arsenic consumption and selected maternal characteristics were estimated using multinomial logistic regression.ResultsEstimates of mean maternal total and inorganic dietary arsenic consumption were 14.9 and 5.2 μg/day, respectively. Several positive and inverse associations with confidence intervals that excluded the null were observed. Comparing mothers in the middle or high total arsenic consumption tertiles to those in the low tertile, we observed positive associations (odds ratios = 1.3–3.8) for maternal age (≥30 years), lower (0–8 years) or higher (>12 years) education, race/ethnicity (non‐Hispanic Black, Hispanic, other), and early pregnancy drinking with no binge episodes, and inverse associations (odds ratios = 0.4–0.8) for age (<25 years), body mass index (≥30.0 kg/m2), and early pregnancy smoking. Findings tended to be similar for inorganic arsenic consumption.ConclusionsThese contemporary estimates of pre‐pregnancy dietary arsenic consumption among U.S. women show associations between both total and inorganic dietary arsenic consumption and several maternal characteristics, improving characterization of the public health impact of this exposure.