MYOCARDIAL-FUNCTION AND TRANSMURAL BLOOD-FLOW DURING CORONARY VENOUS RETROPERFUSION IN PIGS
MYOCARDIAL-FUNCTION AND TRANSMURAL BLOOD-FLOW DURING CORONARY VENOUS RETROPERFUSION IN PIGS
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DOI：
10.1161/01.cir.86.4.1265
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发表时间：
1992-10-01
期刊：
影响因子：
37.8
通讯作者：
ROSS, J
中科院分区：
文献类型：
--
作者：
OH, BH;VOLPINI, M;ROSS, J
背景。在冠状静脉后灌注过程中，局部心肌收缩的恢复程度尚未得到很好的确定，特别是在没有冠状动脉侧支通道的情况下。因此，通过左前降静脉选择性泵后灌注，左前降静脉通气至零压，评估猪冠状静脉后灌注所能获得的最大功能益处。方法与结果。在8头麻醉开胸猪中，在选择性左前降静脉再灌注期间，当再灌注流量为对照动脉流量的200%时，局部心肌功能（收缩期壁增厚百分比）逐渐增加，平均为对照值的62%。随着后灌注血流的增加（从8.7+/-0.9 mm到10.7+/-2.3 mm, p . 1），观察到舒张末期前壁尺寸进行性增厚
Background. The degree of recovery of regional myocardial contraction during coronary venous retroperfusion has not been well established, particularly in the absence of coronary collateral channels. Therefore, the maximal functional benefit attainable with coronary venous retroperfusion was assessed in pigs by means of using selective pump retroperfusion of the left anterior descending vein, with venting of the left anterior descending artery to zero pressure.Methods and Results. In eight anesthetized open-chest pigs during selective left anterior descending venous retroperfusion over a range of retroperfusion flows, regional myocardial function (percent systolic wall thickening by sonomicrometry) increased progressively to an average of 62% of control values at a retroperfusion flow rate 200% of control arterial flow. Progressive thickening of the end-diastolic dimension of the anterior wall was observed with increasing retroperfusion flow (from 8.7+/-0.9 to 10.7+/-2.3 mm, p