HIV-1 Antigens in Neurons of Cocaine-Abusing Patients.
HIV-1 Antigens in Neurons of Cocaine-Abusing Patients.
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DOI：
10.2174/1874357900802010024
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Lossinsky AS
中科院分区：
文献类型：
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作者：
Fiala M;Singer EJ;Commins D;Mirzapoiazova T;Verin A;Espinosa A;Ugen K;Bernas M;Witte M;Weinand M;Lossinsky AS
皮质醇通过解除靶基因转录的调节打开血脑屏障。在这里，我们表明，可卡因在药物滥用者的血液浓度破坏内皮细胞连接的细胞外信号调节激酶，豆蔻酰化的富含丙氨酸的C激酶和肌球蛋白轻链的磷酸化信号。由于HIV-1相关性痴呆的药物滥用患者的神经元显示出gp 120、p24和Nef，因此，在体内，cobalt效应可能是重要的。
Cocaine opens the blood-brain barrier by deregulating transcription of target genes. Here we show that cocaine at blood concentrations in drug abusers disrupts endothelial cell junctions in parallel with signaling by phosphorylation of extracellular signal-regulated kinase, myristoylated alanine-rich C kinase and myosin light chain. Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef.