Strengthening of top-down frontal cognitive control networks underlying the development of inhibitory control: a functional magnetic resonance imaging effective connectivity study.
Strengthening of top-down frontal cognitive control networks underlying the development of inhibitory control: a functional magnetic resonance imaging effective connectivity study.
复制标题
DOI：
10.1523/jneurosci.2825-10.2010
复制
发表时间：
2010-11-17
期刊：
影响因子：
--
通讯作者：
Luna B
中科院分区：
文献类型：
--
作者：
Hwang K;Velanova K;Luna B
主动抑制对任务无关刺激的反应的能力是认知控制的基本组成部分，在青春期有一个长期的发展。先前的人类发育成像研究发现儿童和青少年的局部大脑活动不成熟。然而，人们对这些区域如何与年龄相结合，形成支持认知控制的分布式网络知之甚少。在本研究中，我们使用格兰杰因果关系分析来表征发展变化的有效连接的抑制控制（antisaccade任务）相比，反射性反应（正面任务）在人类参与者。到了童年，很少有自上而下的连接是明显的，增加顶叶的互连。到了青春期，前额叶皮层的连接增加，顶叶的连接减少。从青春期到成年期，有证据表明，额叶与皮层区域以及皮层下区域的连接数量和强度都有所增加。总而言之，结果表明，抑制控制的发育改善可能得到与年龄相关的额叶、动眼神经和皮质下区域之间自上而下的有效连接增强的支持。
The ability to voluntarily inhibit responses to task irrelevant stimuli, which is a fundamental component of cognitive control, has a protracted development through adolescence. Prior human developmental imaging studies have found immaturities in localized brain activity in children and adolescents. However, little is known about how these regions integrate with age to form the distributed networks known to support cognitive control. In the present study, we used Granger Causality analysis to characterize developmental changes in effective connectivity underlying inhibitory control (antisaccade task) compared to reflexive responses (prosaccade task) in human participants. By childhood few top-down connectivity were evident with increased parietal interconnectivity. By adolescence connections from prefrontal cortex increased and parietal interconnectivity decreased in number. From adolescence to adulthood there was evidence of increased number and strength of frontal connections to cortical regions as well as subcortical regions. Taken together, results suggest that developmental improvements in inhibitory control may be supported by age related enhancements in top-down effective connectivity between frontal, oculomotor and subcortical regions.