Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries
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DOI：
10.1038/leu.2012.26
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发表时间：
2012-07-01
期刊：
影响因子：
11.4
通讯作者：
Chen, S-J
中科院分区：
文献类型：
--
作者：
Chen, B.;Wang, Y-Y;Chen, S-J
白血病的诊断、治疗和预后评估在很大程度上依赖于对遗传异常的充分识别。本文对1346例初治急性淋巴细胞白血病（ALL）患者的遗传畸变进行了系统分析。儿童组高二倍体和t（12;21）（p13;q22）/ETV 6-RUNX 1的发生率明显高于成人组（P < 0.0001），而成人组IKZF 1基因Ph和Ik 6变异的发生率明显高于儿童组（P均< 0.0001）。在B-ALL中，Ik 6的表达与BCR-ABL的表达有显著相关性（P < 0.0001）。与西方队列相比，我们组中t（9;22）（q34;q11）/BCR-ABL（14.60%）和HOX 11在T-ALL中表达（25.24%）的发生率似乎更高，而t（12; 21）（p13; q22）/ETV 6-RUNX 1（15.34%）在中国儿童患者中的发生率似乎更低。在我们的研究中，儿童（10.61% vs 20 - 38%）或成人患者（2.36% vs 6.77 - 12%）的超二倍体发生率远低于西方报道。此外，在我们的队列中，成人患者中HOX 11 L2的频率远高于西方国家（20.69% vs 4 - 11%）。总的来说，中国ALL患者比西方患者具有更多的不良预后因素。
It has been generally acknowledged that the diagnosis, treatment and prognosis evaluation of leukemia largely rely on an adequate identification of genetic abnormalities. A systemic analysis of genetic aberrations was performed in a cohort of 1346 patients with newly diagnosed acute lymphoblastic leukemia (ALL) in China. The pediatric patients had higher incidence of hyperdiploidy and t(12;21) (p13;q22)/ETV6 - RUNX1 than adults (P < 0.0001); in contrast, the occurrence of Ph and Ik6 variant of IKZF1 gene was much more frequent in adult patients (all P < 0.0001). In B-ALL, the existence of Ik6 and that of BCR - ABL were statistically correlated ( P < 0.0001). In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR - ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12; 21) ( p13; q22)/ETV6 - RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. The occurrence of hyperdiploidy was much lower either in pediatric (10.61% vs 20 - 38%) or adult patients (2.36% vs 6.77 - 12%) in our study than in Western reports. In addition, the frequencies of HOX11L2 in adult patients were much higher in our cohort than in Western countries (20.69% vs 4 - 11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do.