Alcohol consumption, mild cognitive impairment, and progression to dementia
Alcohol consumption, mild cognitive impairment, and progression to dementia
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DOI：
10.1212/01.wnl.0000262035.87304.89
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发表时间：
2007-05-22
期刊：
影响因子：
9.9
通讯作者：
Panza, F.
中科院分区：
文献类型：
--
作者：
Solfrizzi, V.;D'Introno, A.;Panza, F.
目的：评估饮酒对轻度认知障碍发生率及其进展为痴呆的影响。方法：我们评估了 1,445 名非认知障碍患者的轻度认知障碍发生率，以及 121 名年龄 65 至 84 岁的轻度认知障碍患者的痴呆进展情况，这些患者参与了意大利老龄化纵向研究，并进行了 3.5 年的随访。酒精消费水平是在调查前一年确定的。使用当前的临床标准对痴呆和轻度认知障碍进行分类。结果：患有轻度认知障碍的中度饮酒者，即每天饮酒量少于 1 杯（约 15 克酒精）的患者，进展为痴呆的比率低于戒酒者（风险比 [HR] 0.15；95% CI 0.03 至 0.78）。此外，患有轻度认知障碍的中度饮酒者（每天饮酒量少于 1 杯）的痴呆进展率显着低于戒酒者（HR 0.15；95% CI 0.03 至 0.77）。最后，与戒酒者相比，轻度认知障碍患者的较高饮酒水平（>= 1 杯/天）与痴呆进展率之间没有显着相关性。在非认知障碍人士与戒酒者中，任何饮酒水平与轻度认知障碍的发生率之间均未发现显着关联。结论：在患有轻度认知障碍的患者中，每天饮酒最多 1 杯酒精或葡萄酒可能会降低进展为痴呆的速度。
Objective: To estimate the impact of alcohol consumption on the incidence of mild cognitive impairment and its progression to dementia. Methods: We evaluated the incidence of mild cognitive impairment in 1,445 non-cognitively impaired individuals and its progression to dementia in 121 patients with mild cognitive impairment, aged 65 to 84 years, participating in the Italian Longitudinal Study on Aging, with a 3.5-year follow-up. The level of alcohol consumption was ascertained in the year before the survey. Dementia and mild cognitive impairment were classified using current clinical criteria. Results: Patients with mild cognitive impairment who were moderate drinkers, i.e., those who consumed less than 1 drink/day (approximately 15 g of alcohol), had a lower rate of progression to dementia than abstainers (hazard ratio [HR] 0.15; 95% CI 0.03 to 0.78). Furthermore, moderate drinkers with mild cognitive impairment who consumed less than 1 drink/ day of wine showed a significantly lower rate of progression to dementia than abstainers (HR 0.15; 95% CI 0.03 to 0.77). Finally, there was no significant association between higher levels of drinking (>= 1 drink/ day) and rate of progression to dementia in patients with mild cognitive impairment vs abstainers. No significant associations were found between any levels of drinking and the incidence of mild cognitive impairment in non-cognitively impaired individuals vs abstainers. Conclusions: In patients with mild cognitive impairment, up to 1 drink/day of alcohol or wine may decrease the rate of progression to dementia.