Cytomegalovirus: pathogen, paradigm, and puzzle
Cytomegalovirus: pathogen, paradigm, and puzzle
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DOI：
10.1172/jci45449
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发表时间：
2011-05-01
影响因子：
15.9
通讯作者：
Geballe, Adam P.
中科院分区：
文献类型：
--
作者：
Boeckh, Michael;Geballe, Adam P.
人巨细胞病毒（CMV）是常见的八种感染人类的疱疹病毒之一，最为人所知的是其在免疫功能低下的患者中引起疾病的倾向，特别是移植受体、晚期AIDS患者和先天性感染的新生儿。分子病毒学的进步，加上诊断方法和治疗方案的改进，极大地提高了我们对CMV的理解和管理能力，但仍存在许多不确定性，包括持久性和发病机制及其在各种人类疾病中的假设作用。在这里，我们回顾了最近的进展，这些进展正在重塑我们对这种迷人病毒的看法和方法。
Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect humans, is best known for its propensity to cause disease in immunocompromised patients, especially transplant recipients, patients with advanced AIDS, and congenitally infected newborns. Advances in molecular virology coupled with improvements in diagnostic methods and treatment options have vastly improved our understanding of and ability to manage CMV, but many uncertainties remain, including the mechanisms of persistence and pathogenesis and its hypothesized roles in a variety of human illnesses. Here we review recent advances that are reshaping our view and approach to this fascinating virus.