Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants
Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants
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DOI：
10.1248/bpb.b14-00037
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发表时间：
2014-06-01
影响因子：
2
通讯作者：
Yoshikawa, Masayuki
中科院分区：
文献类型：
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作者：
Matsuda, Hisashi;Nakamura, Seikou;Yoshikawa, Masayuki
过氧化物酶体增殖物激活受体γ(PPARγ)的有效配体，如噻唑烷二酮(吡格列酮、曲格列酮等)。通过增加脂肪组织中与胰岛素敏感性相关的重要脂肪细胞因子脂联素的水平来改善胰岛素敏感性。最近报道了一些药用植物成分在3T3-L1细胞中显示出PPARγ激动剂样活性，但在不同于噻唑烷二酮类化合物的受体位置上没有显示出激动剂活性。我们最近对八仙花炮制叶中的PPAR伽马激动剂类成分，如绣球烯醇和绣球酸进行了研究。综述了从胡椒果实中分离得到的胡椒素、胡椒素和逆曲霉胺A，以及从山奈子根茎中分离得到的四甲基山奈酚和五甲基栎素。
Potent ligands of peroxisome proliferator-activated receptor gamma (PPAR gamma) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPAR gamma agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPAR gamma agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii, piperlonguminine and retrofractamide A from the fruit of Piper chaba, and tetramethylkaempferol and pentamethylquercetin from the rhizomes of Kaempferia parviflora, are reviewed.