An Identical Translocation between Chromosome 1 and 7 in Three Patients with Myelofibrosis and Myeloid Metaplasia
An Identical Translocation between Chromosome 1 and 7 in Three Patients with Myelofibrosis and Myeloid Metaplasia
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DOI：
10.1111/j.1365-2141.1980.tb08711.x
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发表时间：
1980-04
影响因子：
6.5
通讯作者：
J. Geraedts;G. J. Ottolander;J. E. Ploem;O. G. Muntinghe
中科院分区：
文献类型：
--
作者：
J. Geraedts;G. J. Ottolander;J. E. Ploem;O. G. Muntinghe
概括。在三名不相关的骨髓纤维化和骨髓化生患者中观察到相同的染色体异常，其中两名患者在发生骨髓纤维化之前有真性红细胞增多症（PV）病史。未刺激的外周血培养显示 1 号和 7 号染色体之间的易位取代了第 7 号染色体对的同源物。通过 G 和 C 显带将其鉴定为 t(1;7)(7pter→7p11::1p1?→1qter)。
Summary. An identical chromosome abnormality was observed in three unrelated patients with myelofibrosis and myeloid metaplasia, two of the patients showing a history of polycythaemia vera (PV) before development of the myelofibrosis. Unstimulated peripheral blood cultures showed a translocation between chromosomes 1 and 7 replacing a homologue of pair 7. It was identified by G‐ and C‐banding as t(1;7)(7pter→7p11::1p1?→1qter).