Postnatal development of intrinsic horizontal axons in macaque inferior temporal and primary visual cortices

Postnatal development of intrinsic horizontal axons in macaque inferior temporal and primary visual cortices
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猕猴颞下皮层和初级视觉皮层内在水平轴突的出生后发育

DOI：
10.1093/cercor/bhw105
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发表时间：
2016
期刊：
Cerebral Cortex
影响因子：
3.7
通讯作者：
Ichiro Fujita (QW and HT contributed equally to this work)
Ichiro Fujita (QW and HT contributed equally to this work)
中科院分区：
医学2区
文献类型：
--
作者：
Quanxin Wang;Hisashi Tanigawa;Ichiro Fujita (QW and HT contributed equally to this work)

文献摘要

相似文献

猕猴腹侧视觉流的两个不同区域，即初级视觉皮层（V1）和下颞叶皮层（TE），在成年动物中表现出不同的内在水平轴突投影模式。这两个区域的斑块之间的差异可能反映了皮层表征和视觉信息处理的差异。我们通过在不同年龄的猴子TE和V1中注射顺行示踪剂来研究斑块的出生后发育。在1周龄时，两个区域已经出现了与成人相似的贴片分布模式。在两个区域，不同年龄的猴子斑块标记强度随投影距离呈指数衰减，但这种趋势在TE中不明显。斑块的数量和范围在V1中随着年龄的增长而逐渐减少，但在TE中没有。在V1中，轴突和钮扣密度仅在短投影距离的斑块中增加，而在TE中，这种密度变化发生在不同投影距离的斑块中。因此，具有区域特异性分布模式的斑块在生命早期形成，而区域特异性的出生后发育过程将形成斑块的连通性，直至成年。
Two distinct areas along the ventral visual stream of monkeys, the primary visual (V1) and inferior temporal (TE) cortices, exhibit different projection patterns of intrinsic horizontal axons with patchy terminal fields in adult animals. The differences between the patches in these 2 areas may reflect differences in cortical representation and processing of visual information. We studied the postnatal development of patches by injecting an anterograde tracer into TE and V1 in monkeys of various ages. At 1 week of age, labeled patches with distribution patterns reminiscent of those in adults were already present in both areas. The labeling intensity of patches decayed exponentially with projection distance in monkeys of all ages in both areas, but this trend was far less evident in TE. The number and extent of patches gradually decreased with age in V1, but not in TE. In V1, axonal and bouton densities increased postnatally only in patches with short projection distances, whereas in TE this density change occurred in patches with various projection distances. Thus, patches with area-specific distribution patterns are formed early in life, and area-specific postnatal developmental processes shape the connectivity of patches into adulthood.