Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus Aspergillus sp 085242
Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus Aspergillus sp 085242
复制标题
Asperterpenols A 和 B，从红树林内生真菌 Aspergillus sp 085242 中分离出的新二倍萜类化合物
DOI：
10.1021/ol401005j
复制
发表时间：
2013-05-17
期刊：
影响因子：
5.2
通讯作者：
She, Zhigang
中科院分区：
文献类型：
--
作者：
Xiao, Ze'en;Huang, Huarong;She, Zhigang
从一株红树林内生真菌Aspergillus sp.085242中分离得到两个新的二萜类化合物--赤萜醇A（1）和赤萜醇B（2）。根据光谱方法和单晶X-射线衍射分析确定的绝对构型对结构进行了阐明。化合物1和2抑制乙酰胆碱酯酶，IC 50值分别为2.3和3.0 μ M。
Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were Isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC50 values of 2.3 and 3.0 mu M, respectively.