Eating in the Absence of Hunger but not Loss of Control Behaviors are Associated with 16p11.2 Deletions
Eating in the Absence of Hunger but not Loss of Control Behaviors are Associated with 16p11.2 Deletions
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DOI：
10.1002/oby.20892
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发表时间：
2014-12-01
期刊：
影响因子：
6.9
通讯作者：
Chung, Wendy K.
中科院分区：
文献类型：
--
作者：
Gill, Richard;Chen, Qixuan;Chung, Wendy K.
BP 4-BP 5 16p11.2缺失约600-kb一直与肥胖相关。我们研究了两个遗传disinhibited饮食行为，在没有饥饿（EAH）和控制（EAH）的损失，以更好地描述删除和肥胖之间的关系。MethodsOur研究人群包括93 16p11.2 CNV载体（64与删除和29与重复）和他们的家庭。我们使用线性混合模型进行分析，并将重点放在缺失携带者上。
ObjectiveThe approximate to 600-kb BP4-BP5 16p11.2 deletion has been consistently associated with obesity. We studied two heritable disinhibited eating behaviors, eating in the absence of hunger (EAH) and loss of control (LOC), to better characterize the relationship between the deletion and obesity.MethodsOur study population included ninety-three 16p11.2 CNV carriers (64 with deletions and 29 with duplications) and their families. We performed analyses using linear mixed models and focused on deletion carriers.ResultsWe confirmed previous associations between the 16p11.2 deletion and obesity (P