HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA
HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA
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DOI：
10.1016/0014-5793(95)00687-5
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发表时间：
1995-07-17
期刊：
影响因子：
3.5
通讯作者：
FORSSMANN, WG
中科院分区：
文献类型：
--
作者：
BENSCH, KW;RAIDA, M;FORSSMANN, WG
我们报道了从人血滤液中分离并鉴定了一种与β-防御素有显著序列同源性的新多肽。人β-防御素-1(HBD-1)是一个由36个氨基酸残基组成的碱性短肽，含有6个半胱氨酸，形成3个分子内二硫键。HBD-1的相对分子质量为3928.6 Da。克隆得到的hBD-1与牛和鸡的呼吸道上皮细胞和中性粒细胞中的β-防御素具有9个保守的氨基酸序列。HBD-1在人血浆中以纳摩尔浓度存在。
We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues, It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide, hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.