Phosphite-Mediated Reductive Cross-Coupling of Isatins and Nitrostyrenes.
Phosphite-Mediated Reductive Cross-Coupling of Isatins and Nitrostyrenes.
复制标题
亚磷酸盐介导的靛红和硝基苯乙烯的还原交叉偶联。
DOI：
10.1055/s-0036-1588170
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Johnson,JeffreyS
中科院分区：
文献类型：
--
作者：
Motevalli,Somayeh;Johnson,JeffreyS
N-烷基靛红、亚磷酸二甲酯和硝基苯乙烯之间的一种新的还原偶联反应已被开发出来。该反应依赖于 Pudovik 加成，随后的膦酸-磷酸重排，以及在吲哚酮上与 β-硝基苯乙烯发生瞬时碳负离子的 Michael 型加成。该协议介绍了一种在温和条件下构建多官能化叔磷酸酯的便捷且通用的方法。手性通用碱催化标题反应，具有良好的对映选择性水平。
A new reductive coupling reaction betweenN-alkylisatins, dimethyl phosphite, and nitrostyrenes has been developed. The reaction relies on Pudovik addition, subsequent phosphonate–phosphate rearrangement, and Michael-type addition of a transient carbanion on the indolinone with β-nitrostyrenes. This protocol introduces a convenient and versatile method for the construction of polyfunctionalized tertiary phosphates under mild conditions. Chiral general bases catalyze the title reaction with promising levels of enantioselectivity.