Enzymes of the gamma-glutamyl cycle in the ciliary body and lens.
Enzymes of the gamma-glutamyl cycle in the ciliary body and lens.
复制标题
睫状体和晶状体中γ-谷氨酰循环的酶。
DOI：
--
复制
发表时间：
1973
影响因子：
11.1
通讯作者：
A. Meister
中科院分区：
文献类型：
--
作者：
L. Ross;L. Barber;S. Tate;A. Meister
γ-谷氨酰循环的酶已在兔睫状体中发现，并且除了 5-氧代脯氨酸酶外，还在眼晶状体中发现。组织化学研究表明，γ-谷氨酰转肽酶主要位于睫状体上皮细胞的基底部分；研究结果与在氯样神经丛中观察到的结果相似。睫状上皮中的组织化学染色反应比氯样丛、肠和肾中的更强烈。肠和肾近曲小管上皮中的γ-谷氨酰转肽酶染色活性仅限于微绒毛边界。在瞳孔后缘虹膜非色素上皮细胞的细胞质中发现中等转肽酶活性。组织化学和酶活性研究与γ-谷氨酰循环在氨基酸跨血-房水屏障转运中发挥作用的论点是一致的。
The enzymes of the gamma-glutamyl cycle have been found in rabbit ciliary body and, except for 5-oxoprolinase, also in the ocular lens. Histochemical studies show that gamma-glutamyl transpeptidase is localized mainly in the basal portions of the epithelial cells of the ciliary body; the findings are similar to those observed in the chloroid plexuses. The histochemical staining reaction in the ciliary epithelium is more intense than in the chloroid plexus, intestine, and kidney. gamma-Glutamyl transpeptidase staining activity in the epithelium of the intestinal and renal proximal convoluted tubules is confined to the microvillus border. Moderate transpeptidase activity was found in the cytoplasm of nonpigmented epithelial cells of the iris at the posterior pupillary margin. The histochemical and enzyme activity studies are consistent with the thesis that the gamma-glutamyl cycle functions in transport of amino acids across the blood-aqueous humor barrier.