Spatial Navigation in Preclinical Alzheimer's Disease.
Spatial Navigation in Preclinical Alzheimer's Disease.
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DOI：
10.3233/jad-150855
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发表时间：
2016-02-09
期刊：
影响因子：
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通讯作者：
Head D
中科院分区：
文献类型：
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作者：
Allison SL;Fagan AM;Morris JC;Head D
尽管之前的几项研究已经证明早期有症状的阿尔茨海默病 (AD) 存在导航缺陷，但临床前 AD 的导航能力尚未得到检验。本研究探讨了临床前 AD 和早期症状性 AD 对空间导航性能的影响。检查了虚拟现实环境中寻路和路线学习任务的性能。对以下三组进行比较：临床正常但无临床前 AD 组 (n = 42)、临床正常但患有临床前 AD 组 (n = 13) 和早期有症状 AD 组 (n = 16)。临床前 AD 的定义是脑脊液 Aβ42 水平低于 500 pg/ml。临床前 AD 与寻路策略的使用缺陷有关，但与路线学习策略的使用缺陷无关。此外，事后分析表明寻路性能具有中等的敏感性和特异性。结果还证实了在使用寻路和路线学习策略方面存在早期症状性 AD 相关缺陷。这项研究的结果表明，空间导航的各个方面对于检测 AD 最早的认知缺陷可能特别敏感。
Although several previous studies have demonstrated navigational deficits in early-stage symptomatic Alzheimer's disease (AD), navigational abilities in preclinical AD have not been examined. The present investigation examined the effects of preclinical AD and early-stage symptomatic AD on spatial navigation performance. Performance on tasks of wayfinding and route learning in a virtual reality environment were examined. Comparisons were made across the following three groups: Clinically normal without preclinical AD (n = 42), clinically normal with preclinical AD (n = 13), and early-stage symptomatic AD (n = 16) groups. Preclinical AD was defined based on cerebrospinal fluid Aβ42 levels below 500 pg/ml. Preclinical AD was associated with deficits in the use of a wayfinding strategy, but not a route learning strategy. Moreover, post-hoc analyses indicated that wayfinding performance had moderate sensitivity and specificity. Results also confirmed early-stage symptomatic AD-related deficits in the use of both wayfinding and route learning strategies. The results of this study suggest that aspects of spatial navigation may be particularly sensitive at detecting the earliest cognitive deficits of AD.