VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY
VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY
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DOI：
10.1038/335835a0
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发表时间：
1988-10-27
期刊：
影响因子：
64.8
通讯作者：
KLEMPNAUER, KH
中科院分区：
文献类型：
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作者：
BIEDENKAPP, H;BORGMEYER, U;KLEMPNAUER, KH
逆转录病毒癌基因v-myb及其细胞前体c-myb编码核DNA结合蛋白1 - 5。Myb基因已在广泛的物种中被鉴定，包括脊椎动物6 -9、果蝇10、11和植物玉米12。v-MYB蛋白的DNA结合结构域定位于高度保守的氨基末端区域11，13表明MYB/DNA相互作用对MYB功能很重要。我们在这里表明，v-MYB特异性识别的核苷酸序列pyAACG/TG。因此，像其他核转化蛋白一样，v-MYB似乎是序列特异性DNA结合因子类的一员，可能参与基因调控。
The retroviral oncogene v-myband its cellular progenitor c-mybencode nuclear DNA-binding proteins1–5.Mybgenes have been identified in a broad range of species, including vertebrates6–9, the fruit flyDrosophila melanogaster10,11and the plantZea mays12. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region11,13suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.