Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.
Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.
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DOI：
10.4049/jimmunol.1601318
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Powell JD
中科院分区：
文献类型：
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作者：
Bettencourt IA;Powell JD
Immune cell activation and differentiation occurs concurrently with metabolic reprogramming. This insures that activated cells generate the energy and substrates necessary to perform their specified function. Likewise, the metabolic programs amongst different cells of the immune system vary. By targeting different metabolic pathways, these differences allow for selective regulation of immune responses. Further, the relative susceptibility of cells to a metabolic inhibitor is dictated by their metabolic demands; cellular selectivity is based on demand. Therefore where differences exist in metabolic pathways between healthy and pathogenic cells, there is opportunity for selective regulation with agents lacking intrinsic specificity. There are now a host of studies demonstrating how inhibitors of metabolism (for example glycolysis, glutamine metabolism, and fatty acid oxidation) can regulate immune responses and treat immune mediated pathogenesis. In this brief review we detail how inhibitors of metabolism can be employed to regulate immune responses in both autoimmunity and transplantation.
