Anterior pituitary hormones, stress, and immune system homeostasis
Anterior pituitary hormones, stress, and immune system homeostasis
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DOI：
10.1002/1521-1878(200103)23:3
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发表时间：
2001-03-01
期刊：
影响因子：
4
通讯作者：
Horseman, ND
中科院分区：
文献类型：
--
作者：
Dorshkind, K;Horseman, ND
大量有争议的文献认为催乳素（PRL）、生长激素（GH）、胰岛素样生长因子-I（IGF-I）和甲状腺激素是关键的免疫调节因子。然而，最近对缺乏这些激素产生或其受体表达的小鼠的研究表明，只有少数情况下淋巴细胞发育或抗原反应需要这些激素。相反，他们的主要作用是抵消负面的免疫调节因子的影响，如糖皮质激素，当生物体受到重大压力时产生。在这些情况下，PRL、GH、IGF-I和/或甲状腺激素的免疫保护作用可确保免疫系统稳态并降低对应激诱导的疾病的易感性。这些免疫增强作用可以在临床上用于免疫系统因疾病或各种治疗方案而受到抑制的情况。BioEssays 23：288-294，2001年。(C)John Wiley & Sons，Inc.
An extensive, and controversial, literature concluding that prolactin (PRL), growth hormone (GH), insulin-like growth factor-I (IGF-I), and thyroid hormones are critical immunoregulatory factors has accumulated. However, recent studies of mice deficient in the production of these hormones or expression of their receptors indicate that there are only a few instances in which these hormones are required for lymphocyte development or antigen responsiveness. Instead, a case is made that their primary role is to counteract the effects of negative immunoregulatory factors, such as glucocorticoids, which are produced when the organism is subjected to major stressors. The immunoprotective actions of PRL, GH, IGF-I, and/or thyroid hormones in these instances may ensure immune system homeostasis and reduce the susceptibility to stress-induced disease. These immune-enhancing effects could be exploited clinically in instances where the immune system is depressed due to illness or various treatment regimens. BioEssays 23:288-294, 2001. (C) 2001 John Wiley & Sons, Inc.