Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes
Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes
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DOI：
10.1016/j.diabres.2010.01.013
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发表时间：
2010-04-01
影响因子：
5.1
通讯作者：
Li, Qiang
中科院分区：
文献类型：
--
作者：
Pan, Hong-Yan;Guo, Lin;Li, Qiang
目的：检测不同糖调节水平人群血清网膜素-1水平，分析血清网膜素-1水平与体重指数（BMI）、糖化血红蛋白（HbA 1c）、血糖、胰岛素抵抗指数（HOMA-IR）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）水平的关系。46例糖调节受损（IGR）患者，55例新诊断和未经治疗的2型糖尿病（T2 DM）患者，正常糖耐量（NGT）受试者50例。测定空腹和糖负荷后2 h的血清网膜素-1和血糖水平以及空腹血清TNF-α、IL-6、胰岛素和HbA 1c水平。结果：IGR组和T2 DM组血清网膜素-1水平低于NGT组。组内网膜素-1水平在糖负荷前后无显著性差异。血清网膜素-1水平与BMI、HOMA-IR、空腹胰岛素、TNF-α、IL-6、血糖呈负相关。HOMA-IR和BMI是影响血清omentin-1水平的独立相关因素。结论：糖调节受损患者血清omentin-1水平降低。网膜素-1的缺乏可能导致胰岛素抵抗和T2 DM的发展。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Aims: To assay the levels of serum omentin-1 in subjects with different levels of glucose regulation and to analyze the relationship between serum omentin-1 levels and body mass index (BMI), glycoslated hemoglobin (HbA1c), plasma glucose, insulin resistance index (HOMA-IR), TNF-alpha and IL-6 levels.Methods: Forty-six patients with impaired glucose regulation (IGR), 55 patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM), and 50 subjects with normal glucose tolerance (NGT) were enrolled in this study. The levels of serum omentin-1 and plasma glucose at fasting and at 2 h after glucose load and fasting serum levels of TNF-alpha, IL-6, insulin, and HbA1c were measured. HOMA-IR was calculated.Results: The levels of serum omentin-1 were lower in the IGR and T2DM groups than in the NGT group. Within groups, omentin-1 levels were no significant difference before and after glucose load. The level of serum omentin-1 was negatively correlated to BMI, HOMA-IR, fasting insulin, TNF-alpha, IL-6, plasma glucose. HOMA-IR and BMI were independent related factors that influenced the levels of serum omentin-1.Conclusions: Serum omentin-1 levels were decreased in impaired glucose regulation subjects. Lack of omentin-1 may contribute to the development of insulin resistance and T2DM. (C) 2010 Elsevier Ireland Ltd. All rights reserved.