IRRITABLE-BOWEL-SYNDROME IN THE GENERAL-POPULATION
IRRITABLE-BOWEL-SYNDROME IN THE GENERAL-POPULATION
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DOI：
10.1136/bmj.304.6819.87
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发表时间：
1992-01-11
影响因子：
--
通讯作者：
LYDEARD, S
中科院分区：
文献类型：
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作者：
JONES, R;LYDEARD, S
目的 - 确定普通人群中与肠易激综合征临床诊断相一致的症状的患病率。设计 - 向 2280 名受试者发送经过验证的邮寄问卷，这些受试者是从 8 位全科医生名单中随机选择的 10 岁年龄组。使用曼宁标准来定义肠易激综合征。 背景 - 南安普敦的城市人口和汉普郡安多弗的城乡混合人口。 结果 - 71% 的受访者收到了 1620 份调查问卷进行分析，其中 412 份 (25%) 报告称上一年有 6 次以上腹痛发作，350 份 (22%) 报告了与肠易激诊断一致的症状 综合症。男女比例为1:1.38。更多肠易激综合征患者出现便秘和腹泻，35% 的患者报告有直肠出血，而总体患病率为 20%。其他症状和病症包括胃灼热、消化不良、潮红、心悸、偏头痛和泌尿系统症状，在肠易激综合征组中更为常见。患有肠易激综合征的受试者 (12%) 比没有肠易激综合症的受试者 (3%) 更常见儿童期腹痛。三分之一患有肠易激综合症的人在研究期间曾寻求医疗建议（男性：女性比例1：1.21）；就诊行为受到年龄和相关症状存在的影响，在不同全科医生登记的患者之间差异很大，并且与症状严重程度相关性较差。 结论 - 几乎四分之一的普通人群存在与肠易激综合征诊断一致的症状，并且往往与许多其他主诉和病症相关，其中一些可能反映平滑肌功能障碍。
Objective - To determine the prevalence of symptoms compatible with a clinical diagnosis of irritable bowel syndrome in the general population.Design - Validated postal questionnaire sent to 2280 subjects randomly selected in 10 year age bands from the lists of eight general practitioners. The Manning criteria were used to define irritable bowel syndrome.Setting - Urban population in Southampton and mixed urban-rural population in Andover, Hampshire.Results - A response of 71% yielded 1620 questionnaires for analysis, of which 412 (25%) reported more than six episodes of abdominal pain in the preceding year, with 350 (22%) reporting symptoms consistent with the diagnosis of irritable bowel syndrome. The male: female ratio was 1:1.38. More subjects with irritable bowel syndrome had constipation and diarrhoea and 35% with the syndrome reported rectal bleeding compared with an overall prevalence of 20%. Other symptoms and conditions including heartburn, dyspepsia, flushing, palpitations, migraine, and urinary symptoms were significantly more common in the group with irritable bowel syndrome. Abdominal pain in childhood was more common in the subjects with irritable bowel syndrome (12%) than without (3%). One third of the group with irritable bowel syndrome had sought medical advice during the study period (male: female ratio 1:1.21); consultation behaviour was influenced by age and the presence of associated symptoms, varied considerably among patients registered with different general practitioners, and was poorly correlated with symptom severity.Conclusion - Symptoms consistent with a diagnosis of irritable bowel syndrome are present in almost one quarter of the general population and tend to be associated with a number of other complaints and conditions, some of which may reflect smooth muscle dysfunction.