A comparative profile of the prevalence and age distribution of human papillomavirus type 16/18 infections among three states of India with focus on northeast India
A comparative profile of the prevalence and age distribution of human papillomavirus type 16/18 infections among three states of India with focus on northeast India
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DOI：
10.1111/j.1525-1438.2007.00827.x
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发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Mukhopadhyay, S.
中科院分区：
文献类型：
--
作者：
Laikangbam, P.;Sengupta, S.;Mukhopadhyay, S.
采用聚合酶链反应检测印度东北部曼尼普尔（n = 692）和锡金（n = 415）已婚妇女宫颈刮片中人乳头瘤病毒（HPV）DNA，并与印度东部西孟加拉（n = 1112）妇女进行比较。曼尼普尔的HPV感染率（7.4%）低于锡金（12.5%），紧随其后的是西孟加拉（12.9%）。HPV 18在曼尼普尔占优势（2.03%），在锡金和西孟加拉（0.9%）明显较低（0.2%），而HPV 16则相反。在宫颈细胞学检查正常的妇女中，曼尼普尔（3.3%，22/672）和锡金（3.89%，14/359）的HPV 16/18感染比例与西孟加拉（7.8%，79/1007）相当，且显著低于后者。这种流行率在曼尼普尔所有年龄组中相似：锡金妇女随年龄增长而增加，西孟加拉妇女随年龄增长而下降，与以前报告的情况相似。年龄在30岁，在西孟加拉年龄在30岁的人中同样如此。因此，与来自西孟加拉的妇女相比，来自印度东北部，特别是来自曼尼普尔的妇女对HPV 16/18感染和相关宫颈病变的易感性似乎较低，在西孟加拉邦，这种易感性在年龄上非常明显
Human papillomavirus (HPV) DNA in cervical scrape samples of married women from Manipur (n = 692) and Sikkim (n = 415) in northeast India was determined and compared with that of women from West Bengal (n = 1112) in eastern India by polymerase chain reaction. HPV prevalence was lower in Manipur (7.4%) than in Sikkim (12.5%), which was closely followed by West Bengal (12.9%). HPV18 was predominant in Manipur (2.03%) and strikingly lower (0.2%) in Sikkim and West Bengal (0.9%), while the reverse was true for HPV16. The proportion of HPV16/18 infections in Manipur (3.3%, 22/672) and Sikkim (3.89%, 14/359) were comparable and significantly lower compared to that in West Bengal (7.8%, 79/1007) among women having normal cervical cytology. Such prevalence was similar among all age groups in Manipur: increased with age for women in Sikkim and dropped with age for those in West Bengal similar to that reported previously. At age 30 years and equally among those in West Bengal aged 30 years. Thus, women from northeast India, particularly from Manipur, appear less susceptible to HPV16/18 infection and related cervical lesions compared to those from West Bengal, where such proneness was prominently evident at age