Elemental content of erythrocytes from patients undergoing Coronary Artery Bypass Grafting (CABG) surgery using PIXE analysis
Elemental content of erythrocytes from patients undergoing Coronary Artery Bypass Grafting (CABG) surgery using PIXE analysis
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DOI：
10.1007/s10967-006-0274-7
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发表时间：
2006-09-01
影响因子：
1.6
通讯作者：
Spyrou, N. M.
中科院分区：
文献类型：
--
作者：
Admans, L. L.;Jeynes, C.;Spyrou, N. M.
这项正在进行的研究是针对红细胞进行的，以进一步确定接受冠状动脉搭桥术 (CABG) 手术的患者血液成分中元素的含量。由于这些样品中元素的质量和数量未知，因此选择质子诱导 X 射线发射 (PIXE) 分析，因为它具有对小质量样品的多元素分析能力。先前的工作证明了使用 PIXE 分析检测了多种元素，并且 S、Cl、Ca 和 Fe 的元素浓度值得注意。这表明，对这些细胞组分的持续分析对于微量元素代谢的研究可能具有重要意义，因为它可以深入了解预防、诊断和治疗目的的机制，从而了解患者的健康状况。在手术前、术中和术后时间点进行红细胞分析，以研究手术干预期间和术后发生的变化。在所有手术时间点的红细胞中均检测到元素 Na、Mg、Si、P、S、Cl、K、Ca、Fe、Cu、Zn、Br 和 Rb，并且从归一化图表中，元素 S、K 和 Fe 显示手术期间浓度的变化遵循几乎相同的模式。预计从长远来看，数据的统计相关性和解释可能会提供对患者康复率或适当的术后护理产生影响的信息。
This on-going study was conducted on erythrocytes to further establish the content of elements of blood fractions from patients undergoing Coronary Artery Bypass Grafting (CABG) surgery. As the quality and quantity of elements in these samples were unknown, proton induced X-ray emission (PIXE) analysis was chosen for its multi-elemental analysis capabilities on small mass samples. Previous work demonstrated the detection of several elements using PIXE analysis and that the elemental concentrations of S, Cl, Ca and Fe were worthy of note. It is indicated that continuing analysis of these cell fractions may be significant in the study of trace element metabolism as it provides insight into understanding mechanisms for preventative, diagnostic and therapeutic purposes and hence a patient's state of health. The analysis of erythrocytes was conducted at pre, during and post-operative timepoints to investigate the changes that occur during and post-surgical intervention. Elements Na, Mg, Si, P, S, Cl, K, Ca, Fe, Cu, Zn, Br and Rb were detected in erythrocytes at all surgery timepoints and from normalized graphs, elements S, K and Fe revealed that the changes in concentration through surgery followed an almost identical pattern. It is anticipated that statistical correlation and interpretation of data may provide, in the long-term, information that could have an impact on the patients' rate of recovery or appropriate aftercare.