MnO2-Based nanosystems for cancer therapy
MnO2-Based nanosystems for cancer therapy
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用于癌症治疗的基于 MnO2 的纳米系统
DOI：
10.1039/d0cc02782k
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发表时间：
2020
影响因子：
4.9
通讯作者：
Shiguo Sun
中科院分区：
文献类型：
--
作者：
Jia Wen;Kui Yang;Shiguo Sun
癌症是世界上最危险的疾病之一，其治疗仍然是一个很大的问题。临床生物医学需求的不断增长和纳米技术的快速发展，迅速促进了用于各种癌症治疗的各种纳米系统的产生。二氧化锰（MnO2）及其纳米复合材料作为一种具有氧化还原活性的过渡金属二氧化物纳米材料，由于其具有比表面积大、吸附降解能力强、荧光猝灭能力强、氧化催化活性高等特点，在肿瘤治疗中显示出上级优势和前所未有的性能。MnO2可分为MnO2纳米片、MnO2量子点、MnO2纳米晶、MnO2纳米线等。本文首先介绍了MnO2，特别是MnO2纳米片的合成方法，然后介绍了MnO2纳米材料的分类。综述了近年来二氧化锰及其纳米复合材料在肿瘤治疗中的应用，主要分为化疗、光疗和协同治疗三大类。此外，还讨论了基于MnO2及其纳米复合材料的其他疾病的治疗。最后，还讨论了合理设计和构建基于MnO 2的纳米系统以进一步生物医学应用的一些关键未解决的问题、可能面临的挑战和未来前景。
Cancer is one of the most dangerous diseases worldwide, the treatment of which is still a great problem. The increasing demand of clinical biomedicine and fast development of nanotechnology have quickly promoted the generation of diverse nanosystems for various cancer therapies. As one kind of redox active transition-metal dioxide nanomaterials, manganese dioxide (MnO2) and its nanocomposites have emerged as a novel class of nanomaterials that show superior advantages and unprecedented performances in cancer therapy due to their large surface area, good absorption and degradation ability, strong fluorescence quenching ability, high oxidation and catalytic activity, etc. According to different morphologies of MnO2, MnO2 can be divided into MnO2 nanosheets, MnO2 quantum dots (QDs), MnO2 nanocrystals, MnO2 nanowires, etc. In this review, the synthesis of MnO2, especially MnO2 nanosheets, is first introduced, followed by an introduction of the classification of MnO2 nanomaterials. Then, recent cancer therapeutic applications of MnO2 and its nanocomposites are comprehensively overviewed, which are categorized into three parts: chemotherapy, phototherapy and synergistic therapy. In addition, treatment of other diseases based on MnO2 and its nanocomposites is also discussed. Finally, some crucial unresolved problems, probable challenges and future perspectives about the rational design and construction of MnO2-based nanosystems for further biomedical applications are also discussed.