Drosophila tools and assays for the study of human diseases.
Drosophila tools and assays for the study of human diseases.
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DOI：
10.1242/dmm.023762
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发表时间：
2016-03
影响因子：
4.3
通讯作者：
Bellen HJ
中科院分区：
文献类型：
--
作者：
Ugur B;Chen K;Bellen HJ
果蝇的许多内脏器官系统在功能上与脊椎动物（包括人类）的内脏器官系统相似。尽管人类和果蝇在总体形态和细胞特征方面存在很大差异，但许多控制发育并驱动细胞和生理过程的分子机制在两种生物体之间是保守的。形态上的差异具有欺骗性，导致研究人员低估了无脊椎动物器官在揭示疾病致病机制方面的研究。在这篇综述和随附的海报中，我们强调了果蝇和人体器官之间的生理和分子相似性，验证了果蝇用于研究人类疾病的分子发病机制。我们讨论了在果蝇中开发的用于研究中枢神经系统、心脏、肝脏和肾脏中特定基因功能的测定方法，并提供了使用这些测定方法来解决与人类疾病相关的问题的示例。这些测定为我们提供了简单而强大的工具来研究与人类致病基因相关的致病机制。编辑选择 - 果蝇系列：在这篇评论和随附的海报中，我们强调了果蝇和人体器官之间的生理和分子相似性，验证了果蝇用于研究人类疾病的分子发病机制。
Many of the internal organ systems of Drosophila melanogaster are functionally analogous to those in vertebrates, including humans. Although humans and flies differ greatly in terms of their gross morphological and cellular features, many of the molecular mechanisms that govern development and drive cellular and physiological processes are conserved between both organisms. The morphological differences are deceiving and have led researchers to undervalue the study of invertebrate organs in unraveling pathogenic mechanisms of diseases. In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. We discuss assays that have been developed in flies to study the function of specific genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes. Editors' choice - Drosophila Collection: In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases.