Embolization with cellulose porous beads, II: Clinical trial.
Embolization with cellulose porous beads, II: Clinical trial.
复制标题
纤维素多孔珠栓塞，II：临床试验。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
Yukitaka Ushio
中科院分区：
文献类型：
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作者：
J. Hamada;Y. Kai;S. Nagahiro;Nobuo Hashimoto;H. Iwata;Yukitaka Ushio
目的
目的：评价纤维素多孔珠(CPB)作为永久性血管闭塞材料的临床适用性。
方法
16例行CPBS栓塞术，其中蝶骨脑膜瘤6例，穹隆脑膜瘤2例，天幕脑膜瘤3例，硬脑膜动静脉瘘2例，副神经节瘤1例，脊髓动静脉畸形2例。对手术标本进行组织学检查。
结果
16例患者中无一例出现并发症。栓塞术后血管造影均显示满意的血管淤滞。手术标本的组织学检查显示，与CPB颗粒口径大致相同的血管被闭塞，但管壁没有拉伸。较大的血管被许多颗粒的聚集体遮挡，没有留下空隙。虽然在血栓形成的血管中可见少量炎症细胞，但CPB引起的炎症较轻，既不会扩散到血管壁，也不会扩散到周围组织。
结论
与其他栓塞剂不同，CPB易于通过微导管注入，可到达远端部位，可产生均匀的周边栓塞物，无炎性改变。在临床环境中，CPB是一种很好的永久闭塞材料。
PURPOSE
To evaluate the clinical applicability of cellulose porous beads (CPBs) as an embolic material for permanent vascular occlusion.
METHODS
Embolization with CPBs was performed in 16 patients, six with meningioma of the sphenoid wing, two with meningioma of the falx, three with meningioma of the tentorium, two with dural arteriovenous fistula, one with paraganglioma, and two with spinal arteriovenous malformation. Surgical specimens were examined histologically.
RESULTS
No complications were encountered in any of the 16 patients. Angiograms obtained after embolization showed satisfactory vascular stasis in all cases. Histologic examination of surgical specimens disclosed that vessels having approximately the same caliber as the CPB particles were occluded without stretching of the vessel wall. Larger vessels were occluded by aggregates of many particles, which left no open spaces. Although a few inflammatory cells were seen in the thrombosed vessels, inflammation evoked by CPB was mild and did not extend to either the vessel wall or to surrounding tissues.
CONCLUSION
CPBs were easy to inject through microcatheters, traveled to distal sites, and produced homogeneous and peripheral embolization without inflammatory changes different from other embolic materials. CPBs are a good embolic material for permanent occlusion in the clinical setting.