The multi-test system: a standardized approach to evaluation of delayed hypersensitivity and cell-mediated immunity.
The multi-test system: a standardized approach to evaluation of delayed hypersensitivity and cell-mediated immunity.
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多重测试系统：评估迟发性超敏反应和细胞介导免疫的标准化方法。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
M. Roumiantzeff
中科院分区：
文献类型：
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作者：
W. Kniker;C. T. Anderson;M. Roumiantzeff
虽然使用普遍存在的抗原进行延迟性皮肤超敏反应（DCH）测试被认为是评估细胞介导免疫的有用方法，但现有方法缺乏标准化的抗原和最佳剂量。作者已经评估了一种新的塑料一次性装置（Multi-Test，林肯实验室），用于同时给药多达8种测试材料，通过多次穿刺和7种普遍存在的抗原，由梅里埃研究所制备的70%甘油。每个抗原都经过化学和生物标准化以测定DCH活性。多重测试系统被证明是一种安全、快速、无痛和可重复的评估DCH对多种标准化抗原的方法。这个程序提供了检测细胞介导的免疫变化的潜力，疾病个体定期皮肤测试。
While delayed cutaneous hypersensitivity (DCH) testing with ubiquitous antigens is acknowledged to be useful in assessment of cell mediated immunity, existing methods suffer from lack of standardized antigens and optimal doses. The authors have evaluated a new plastic, disposable device (Multi-Test, Lincoln Laboratories) for simultaneous administration of up to eight test materials by multiple puncture and seven ubiquitous antigens in 70% glycerol prepared by Institut Merieux. Each antigen was standardized chemically and biologically for DCH activity. The Multi-Test system proved to be safe, rapid, painless, and reproducible means of evaluating DCH to multiple standardized antigens. This procedure offers the potential for detecting changes in cell-mediated immunity in diseases individuals who are skin tested periodically.