Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.
Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.
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DOI：
10.3904/kjim.2011.26.1.8
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Fukuda T
中科院分区：
文献类型：
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作者：
Arima M;Fukuda T
前列腺素D2（PGD2）是一种主要的前列腺素，主要由肥大细胞产生，在过敏性疾病，包括支气管哮喘。PGD2诱导的血管舒张和通透性增加是众所周知的经典效应，可能参与过敏性炎症。最近，PGD2的新功能已被确定。迄今为止，D前列腺素受体（DP）和TH2细胞（CRTH2）上表达的化学引诱物受体同源分子已被证明是主要的PGD2相关受体。这两种受体具有通过调节各种细胞类型（如TH 2细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、树突状细胞和上皮细胞）的功能来介导过敏性疾病的关键作用。本文就PGD2及其代谢产物在TH2炎症及支气管哮喘发病机制中的作用作一综述。
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be involved in allergic inflammation. Recently, novel functions of PGD2 have been identified. To date, D prostanoid receptor (DP) and chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) have been shown to be major PGD2-related receptors. These two receptors have pivotal roles mediating allergic diseases by regulating the functions of various cell types, such as TH2 cells, eosinophils, basophils, mast cells, dendritic cells, and epithelial cells. This review will focus on the current understanding of the roles of PGD2 and its metabolites in TH2 inflammation and the pathogenesis of bronchial asthma.