C-elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
C-elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
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DOI：
10.1016/s0896-6273(00)81199-x
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发表时间：
2000-06-01
期刊：
影响因子：
16.2
通讯作者：
Horvitz, HR
中科院分区：
文献类型：
--
作者：
Sawin, ER;Ranganathan, R;Horvitz, HR
秀丽隐杆线虫通过两种方式调节其运动速率以响应其食物和细菌。首先，喂养良好的野生型动物在有细菌的情况下比没有细菌的情况下移动得更慢。这种基础减慢反应是由含有多巴胺的神经回路介导的，该神经回路感知细菌的机械属性，并且可能是一种适应性机制，可以增加动物在食物存在下花费的时间。其次，缺乏食物的野生动物在转移到细菌中时，会表现出显着增强的减慢反应，确保动物不会离开新遇到的食物来源。这种依赖于经验的反应是由血清素神经传递介导的，并由氟西汀（百忧解）增强。基础和增强的减慢反应是行为可塑性的遗传易处理范式的独特且可分离的神经调节成分。
Caenorhabditis elegans modulates its locomotory rate in response to its food, bacteria, in two ways. First, well-fed wild-type animals move more slowly in the presence of bacteria than in the absence of bacteria. This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that increases the amount of time animals spend in the presence of food. Second, food-deprived wild-type animals, when transferred to bacteria, display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. This experience-dependent response is mediated by serotonergic neurotransmission and is potentiated by fluoxetine (Prozac). The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity.