Biomechanical properties of human and porcine corneas
Biomechanical properties of human and porcine corneas
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DOI：
10.1016/j.exer.2008.02.006
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发表时间：
2008-05-01
影响因子：
3.4
通讯作者：
Rama, Paolo
中科院分区：
文献类型：
--
作者：
Elsheikh, Ahmed;Alhasso, Daad;Rama, Paolo
实验评估了猪角膜作为人类角膜力学特性表征研究中的近似模型的适用性。对37个人供体角膜和34个体外猪角膜在充气条件下进行了测试，以确定它们的短期应力应变行为和长达2.8h的蠕变行为(10,000 S)。从另外12个人角膜和10个猪角膜提取垂直条带，在不同应力水平下进行长达20分钟的应力松弛测试。观察到人和猪的角膜在短期和长期负荷下具有几乎相同的行为形式。它们都表现出非线性的应力-应变行为，并以相似的方式对持续加载做出反应。然而，人的角膜比猪的角膜要硬得多。与猪角膜相比，它们在长期负荷下爬得更少，可以保持更长的压力状态。这些差异，加上早些时候发现的与角膜机械各向异性有关的其他差异，使人怀疑猪角膜是否适合作为机械研究中的人类角膜模型。(C)2008爱思唯尔有限公司。保留所有权利。
The suitability of porcine corneas as approximate models for human corneas in mechanical property characterisation studies is experimentally assessed. Thirty seven human donor corneas and thirty four ex-vivo porcine corneas were tested under inflation conditions to determine their short-term stress-strain behaviour and long-term creep behaviour up to 2.8 h (10,000 s). Vertical strips extracted from further 12 human corneas and 10 porcine corneas were subjected to stress-relaxation tests for up to 20 min at different stress levels. Human and porcine corneas were observed to have almost the same form of behaviour under short and long-term loading. They both exhibited non-linear stress-strain behaviour and reacted to sustained loading in a similar fashion. However, human corneas were significantly stiffer than porcine corneas. They also crept less under long-term loading and could sustain their stress state for longer compared to porcine corneas. These differences, in addition to others identified earlier in relation to corneal mechanical anisotropy, cast doubt on the suitability of porcine corneas as models for human corneas in mechanical studies. (c) 2008 Elsevier Ltd. All rights reserved.