Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
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DOI：
10.1042/bst0350012
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发表时间：
2007-02-01
影响因子：
3.9
通讯作者：
Goldberg, A. L.
中科院分区：
文献类型：
--
作者：
Goldberg, A. L.
本文就蛋白酶体的机制和生物学功能的最新研究进展作一综述。这种依赖于ATP的蛋白质降解复合体是哺乳动物细胞中蛋白质降解的主要部位，并催化泛素化蛋白质的快速降解，也是免疫系统用于筛查病毒和癌症的大多数抗原肽的来源。需要ATP来解开球状蛋白，打开进入20S蛋白酶体的门控通道，并促进蛋白质向其中的翻译。其蛋白分解活性的抑制剂被广泛用作研究工具，并已被证明在癌症治疗中有效。
This review focuses on recent insights into the mechanisms and the biological functions of the proteasome. This large ATP-dependent proteolytic complex is the main site for protein degradation in mammalian cells and catalyses the rapid degradation of ubiquitinated proteins, and is the source of most antigenic peptides used by the immune system to screen for viruses and cancer. ATP is required to unfold globular proteins to open the gated channel into the 20S proteasome and to facilitate protein translation into it. Inhibitors of its proteolytic activity are widely used as research tools and have proven effective in cancer therapy.