The biochemistry of heme biosynthesis
The biochemistry of heme biosynthesis
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DOI：
10.1016/j.abb.2008.02.015
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发表时间：
2008-06-15
影响因子：
3.9
通讯作者：
Jahn, Dieter
中科院分区：
文献类型：
--
作者：
Heinemann, Ilka U.;Jahn, Martina;Jahn, Dieter
血红素是参与多个电子传输链的蛋白质的组成部分，用于几乎所有生命形式中的能量回收。此外，血红素是酶的辅助因子，包括过氧化氢酶、过氧化物酶、P-450类细胞色素和传感器分子的一部分。这里描述了血红素的逐步生物合成，包括所涉及的酶、它们的机制以及它们的失败引起的有害健康后果。报道了不寻常且具有挑战性的生物化学，包括 tRNA 依赖性反应、自由基 SAM 酶和底物衍生的辅助因子。 (c) 2008 Elsevier Inc. 保留所有权利。
Heme is an integral part of proteins involved in multiple electron transport chains for energy recovery found in almost all forms of life. Moreover, heme is a cofactor of enzymes including catalases, peroxidases, cytochromes of the P-450 class and part of sensor molecules. Here the step-by-step biosynthesis of heme including involved enzymes, their mechanisms and detrimental health consequences caused by their failure are described. Unusual and challenging biochemistry including tRNA-dependent reactions, radical SAM enzymes and substrate derived cofactors are reported. (c) 2008 Elsevier Inc. All rights reserved.