Diabetes Mellitus and Risk of Venous Thromboembolism
Diabetes Mellitus and Risk of Venous Thromboembolism
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DOI：
10.1097/maj.0b013e31818bbb8b
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发表时间：
2009-04-01
影响因子：
3.1
通讯作者：
Yaekoub, Abdo Y.
中科院分区：
文献类型：
--
作者：
Stein, Paul D.;Goldman, Jose;Yaekoub, Abdo Y.
背景：确定糖尿病是否是静脉血栓栓塞症(VTE)的危险因素。研究设计和方法：对1979-2005年间全国医院出院调查数据进行分析。采用《国际疾病分类》第九版《临床修订编码》进行疾病识别。结果：在1979-2005年间出院的92,240,000名糖尿病患者中，有1,267,000人(1.4%)患有VTE。VTE的相对风险仅在50岁至59岁以下的患者中升高，在20岁至29岁的患者中最高(相对风险=1.73)。无并发症的I型糖尿病和无并发症的2型糖尿病患者发生VTE的相对风险相似，且与年龄有关。在没有肥胖、中风、心脏病、衰竭或癌症的无并发症糖尿病患者中，与没有糖尿病且没有任何这些并存情况的患者相比，20-29岁患者VTE的相对风险为1.52，30-39岁患者VTE的相对风险为1.19。在老年患者中，糖尿病患者发生VTE的相对风险没有增加。结论：糖尿病增加了VTE的风险，这只在年轻患者中才明显，在这些患者中，不太可能存在增加VTE风险的共病情况。
Background: To determine if diabetes mellitus is a risk factor for venous thromboembolism (VTE). Research Design and Methods: Data from the National Hospital Discharge Survey were analyzed from 1979 to 2005. International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify diseases. Results: Among 92,240,000 patients with diabetes mellitus discharged between 1979 and 2005, 1,267,000 (1.4%) had VTE. The relative risk for VTE was elevated only in patients younger than 50 to 59 years and was highest in patients aged 20 to 29 years (relative risk = 1.73). Relative risks of VTE with uncomplicated type I diabetes mellitus and uncomplicated type 2 diabetes mellitus were similar and also age dependent. In patients with uncomplicated diabetes mellitus who did not have obesity, stroke, heart, failure, or cancer, compared with those who did not have diabetes mellitus and did not have any of these comorbid conditions, the relative risk for VTE was 1.52 in patients aged 20 to 29 years and 1.19 in patients aged 30 to 39 years. In older patients, the relative risk of VTE in patients with diabetes mellitus was not increased. Conclusions: Diabetes mellitus carries an increased risk for VTE, which is apparent only in younger patients in whom comorbid conditions that also increase the risk of VTE are unlikely to be present.