Extracellular matrix and synapse formation.
Extracellular matrix and synapse formation.
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DOI：
10.1042/bsr20212411
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发表时间：
2023-01-31
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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细胞外基质（extracellular matrix，ECM）是一种复杂的分子网络，广泛分布于各种组织和神经系统的细胞外空间。以前的研究已经确定了各种ECM成分，在神经元成熟和信号转导中发挥重要作用。据报道，ECM组分通过与特定受体相互作用或结合而参与神经发生、神经元迁移和轴突生长。此外，发现ECM调节突触形成、突触结构的稳定性和突触可塑性。本文主要综述了细胞外基质中各种成分对突触形成的影响，并简要介绍了几种细胞外基质成分异常引起的相关疾病。
The extracellular matrix (ECM) is a complex molecular network distributed throughout the extracellular space of different tissues as well as the neuronal system. Previous studies have identified various ECM components that play important roles in neuronal maturation and signal transduction. ECM components are reported to be involved in neurogenesis, neuronal migration, and axonal growth by interacting or binding to specific receptors. In addition, the ECM is found to regulate synapse formation, the stability of the synaptic structure, and synaptic plasticity. Here, we mainly reviewed the effects of various ECM components on synapse formation and briefly described the related diseases caused by the abnormality of several ECM components.