Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada
Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada
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DOI：
10.1023/a:1008919408855
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发表时间：
1999-06-01
影响因子：
2.3
通讯作者：
Tibshirani, R
中科院分区：
文献类型：
--
作者：
Green, LM;Miller, AB;Tibshirani, R
目的：为了评估儿童白血病的风险与住宅电磁场（EMF）exposs.Methods：病例对照研究的基础上，88例和133对照使用不同的评估方法，以确定EMF暴露在儿童的当前居住地。病例包括1985-1993年在安大略南部进行的一项大型研究中诊断为0-14岁的白血病患者;人群对照组按年龄和性别分别与病例相匹配。暴露测量的个人监测设备由孩子在家里的日常活动中，在三个房间的时间点测量，并根据电线代码分配给孩子的residence.Results：磁场暴露之间的关联与测量的个人显示器和白血病的风险增加进行了观察。对于那些在6岁以下被诊断出患有急性淋巴细胞白血病的儿童来说，这种风险更明显。在调整功耗和潜在混杂因素后，与磁场相关的风险估计值趋于增加，观察到暴露量大于或等于0.14微特斯拉（mu T）的显著比值比（OR）（OR：4.5，95%置信区间（CI）：1.3-15.9）。在大多数情况下，磁场的时间点测量与风险的非显著升高相关，这与以前的研究基本一致。住宅附近的电力线具有高电流配置与白血病的风险增加无关。暴露于电场测量个人监测与降低白血病risk.Conclusions：磁场暴露直接测量个人监测支持与儿童白血病风险的关联。随着暴露评估的完善，磁场在儿童白血病病因学中的可能作用变得更加明显。
Objectives: To evaluate the risk of childhood leukemia in relation to residential electric and magnetic field (EMF) exposures.Methods: A case control study based on 88 cases and 133 controls used different assessment methods to determine EMF exposure in the child's current residence. Cases comprised incident leukemias diagnosed at 0-14 years of age between 1985-1993 from a larger study in southern Ontario; population controls were individually matched to the cases by age and sex. Exposure was measured by a personal monitoring device worn by the child during usual activities at home, by point-in-time measurements in three rooms and according to wire code assigned to the child's residence.Results: An association between magnetic field exposures as measured with the personal monitor and increased risk of leukemia was observed. The risk was more pronounced for those children diagnosed at less than 6 years of age and those with acute lymphoblastic leukemia. Risk estimates associated with magnetic fields tended to increase after adjusting for power consumption and potential confounders with significant odds ratios (OR) (OR: 4.5, 95% confidence interval (CI): 1.3-15.9) observed for exposures greater than or equal to 0.14 microTesla (mu T). For the most part point-in-time measurements of magnetic fields were associated with non-significant elevations in risk which were generally compatible with previous research. Residential proximity to power lines having a high current configuration was not associated with increased risk of leukemia. Exposures to electric fields as measured by personal monitoring were associated with a decreased leukemia risk.Conclusions: The findings relating to magnetic field exposures directly measured by personal monitoring support an association with the risk of childhood leukemia. As exposure assessment is refined, the possible role of magnetic fields in the etiology of childhood leukemia becomes more evident.