A thermosensory pathway mediating heat-defense responses
A thermosensory pathway mediating heat-defense responses
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DOI：
10.1073/pnas.0913358107
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发表时间：
2010-05-11
影响因子：
11.1
通讯作者：
Morrison, Shaun F.
中科院分区：
文献类型：
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作者：
Nakamura, Kazuhiro;Morrison, Shaun F.
从皮肤温度感受器到中央温度调节系统的温度感觉传入神经传输对于防御体温免受环境热挑战非常重要。在这里，我们报告了一种热感应通路，可触发对环境温度升高的生理热防御反应。利用大鼠体内电生理学和解剖学方法，我们发现臂旁核外侧核（LPBd）背侧的神经元通过谷氨酸将来自脊髓体感神经元的皮肤温暖信号直接传递到温度调节指挥中心——视前区（POA）。有趣的是，这些 LPBd 神经元与另一组神经元相邻，这些神经元介导向 POA 发出皮肤冷信号。功能实验表明，这种 LPBd-POA 温暖感觉通路是引发自主热防御反应所必需的，例如皮肤血管舒张，以应对皮肤变暖的挑战。这些发现为理解维持热稳态的神经回路提供了一个基本框架，这对于在恶劣的环境温度下生存至关重要。
Afferent neural transmission of temperature sensation from skin thermoreceptors to the central thermoregulatory system is important for the defense of body temperature against environmental thermal challenges. Here, we report a thermosensory pathway that triggers physiological heat-defense responses to elevated environmental temperature. Using in vivo electrophysiological and anatomical approaches in the rat, we found that neurons in the dorsal part of the lateral parabrachial nucleus (LPBd) glutamatergically transmit cutaneous warm signals from spinal somatosensory neurons directly to the thermoregulatory command center, the preoptic area (POA). Intriguingly, these LPBd neurons are located adjacent to another group of neurons that mediate cutaneous cool signaling to the POA. Functional experiments revealed that this LPBd-POA warm sensory pathway is required to elicit autonomic heat-defense responses, such as cutaneous vasodilation, to skin-warming challenges. These findings provide a fundamental framework for understanding the neural circuitry maintaining thermal homeostasis, which is critical to survive severe environmental temperatures.