Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
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DOI：
10.1002/cplu.201402286
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发表时间：
2015-04-01
期刊：
影响因子：
3.4
通讯作者：
Gabel, Detlef
中科院分区：
文献类型：
--
作者：
Awad, Doaa;Bartok, Melinda;Gabel, Detlef
发现卤化十二硼酸盐，特别是十二碘十二硼酸盐（2-），有效地触发磷脂脂质体内容物的释放，包括临床上用于癌症治疗的含有二硬脂酰磷脂酰胆碱和胆固醇的脂质体。通过差示扫描量热法、低温透射电子显微镜和原子力显微镜研究了释放的基础。在以高浓度给药后，十二硼酸酯诱导了剧烈的形态学变化。提出了它们在触发释放中的可能应用。
Halogenated dodecaborates, and especially dodecaiodododecaborate(2-), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.