ENHANCED S-CONE-SYNDROME - EVIDENCE FOR AN ABNORMALLY LARGE NUMBER OF S-CONES
ENHANCED S-CONE-SYNDROME - EVIDENCE FOR AN ABNORMALLY LARGE NUMBER OF S-CONES
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DOI：
10.1016/0042-6989(95)98727-q
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发表时间：
1995-05-01
期刊：
影响因子：
1.8
通讯作者：
JACOBSON, SG
中科院分区：
文献类型：
--
作者：
HOOD, DC;CIDECIYAN, AV;JACOBSON, SG
通过分析三名患者的ERG，研究了增强型S视锥综合征患者S（蓝）视锥系统超敏反应的细胞基础。患者对蓝色和白色闪光有较大的a波反应。这些a波被证明几乎完全由S锥驱动。虽然这些S锥a波的大小是正常L/M锥a波的4-6倍，但它们具有相同的形式，并且可以用先前显示的拟合锥a波的相同模型定量描述。我们建议，这些患者的视网膜有更多的S锥比正常的视网膜，这些锥取代一些正常的L/M锥和许多杆。
The cellular basis of the hypersensitivity of the S (blue) cone system in patients with enhanced S cone syndrome was examined by analyzing ERGs from three patients. The patients had large a-waves in response to the blue and white flashes. These a-waves were shown to be driven nearly entirely by the S cones. Although these S cone a-waves were 4-6 times the size of the normal L/M cone a-wave, they are of the same form, and could be quantitatively described with the same model previously shown to fit cone a-waves. We propose that the retina of these patients has many more S cones than the normal retina and that these cones replace some of the normal L/M cones and many of the rods.