Association of Working Memory With Distributed Executive Control Networks in Schizophrenia.
Association of Working Memory With Distributed Executive Control Networks in Schizophrenia.
复制标题
精神分裂症中工作记忆与分布式执行控制网络的关联。
DOI：
10.1176/appi.neuropsych.18060131
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tregellas,JasonR
中科院分区：
文献类型：
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作者：
Wylie,KoreyP;Harris,JosetteG;Ghosh,Debashis;Olincy,Ann;Tregellas,JasonR
工作记忆障碍代表了精神分裂症的核心认知缺陷，可预测患者的日常功能，并且不受当前治疗的影响。为了解决这个问题，工作记忆被纳入MATRICS共识认知测试（MCCB）中，MCCB是一种标准化的认知测试，旨在促进针对认知症状的药物开发。然而，这些赤字MCCB的工作记忆的神经生物学基础是目前未知的，反映在一般精神分裂症的工作记忆缺陷的理解不佳。MethodsTwenty-eight参与者与精神分裂症进行了管理工作记忆测试从MCCB和静息状态功能MRI检查。用独立成分分析估计了内在连通网络。每个体素的时间序列与每个网络时间序列相关，创建用于体素级连通性分析的特征向量。这个特征向量与工作记忆通过使用的距离协方差statistics.ResultsThe MCCB工作记忆测试的神经生物学在很大程度上遵循的多成分模型的工作记忆，但发现意想不到的差异。背外侧前额叶皮层与工作记忆无关。相反，中央执行系统与非定域的左右执行控制网络相关联。语音回路内的多成分模型，一个子系统，参与存储语言信息，与连接到左颞顶交界处和额下回。然而，连接到语言网络并没有预测工作记忆测试performance.ConclusionsThese结果提供支持证据的多成分模型的工作记忆中的生物学基础MCCB的调查结果。
ObjectiveWorking memory impairments represent a core cognitive deficit in schizophrenia, predictive of patients’ daily functioning, and one that is unaffected by current treatments. To address this, working memory is included in the MATRICS Consensus Cognitive Battery (MCCB), a standardized cognitive battery designed to facilitate drug development targeting cognitive symptoms. However, the neurobiology underlying these deficits in MCCB working memory is currently unknown, mirroring the poor understanding in general of working memory deficits in schizophrenia.MethodsTwenty-eight participants with schizophrenia were administered working memory tests from the MCCB and examined with resting-state functional MRI. Intrinsic connectivity networks were estimated with independent component analysis. Each voxel’s time series was correlated with each network time series, creating a feature vector for voxel-level connectivity analysis. This feature vector was associated with working memory by using the distance covariance statistic.ResultsThe neurobiology of MCCB working memory tests largely followed the multicomponent model of working memory but revealed unexpected differences. The dorsolateral prefrontal cortex was not associated with working memory. The central executive system was instead associated with delocalized right and left executive control networks. The phonologic loop within the multicomponent model, a subsystem involved in storing linguistic information, was associated with connectivity to the left temporoparietal junction and inferior frontal gyrus. However, connections to the language network did not predict working memory test performance.ConclusionsThese results provide supporting evidence for the multicomponent model of working memory in terms of the biology underlying MCCB findings.