Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas
Correlation of HER-2 status with estrogen and progesterone receptors and histologic features in 3,655 invasive breast carcinomas
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DOI：
10.1309/ymj3a83tb39mrut9
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发表时间：
2005-04-01
影响因子：
3.5
通讯作者：
Chen, BY
中科院分区：
文献类型：
--
作者：
Lal, P;Tan, LK;Chen, BY
我们使用 HER-2 检测研究了 HER-2 与雌激素 (ER) 和孕激素 (PR) 受体之间的负相关关系，并将 3,655 例未经选择的浸润性乳腺癌的 HER-2 状态与组织学特征相关联。对 ER、PR 和 HER-2 进行免疫组织化学分析，并对 HER-2 进行荧光原位杂交。与 HER-2 肿瘤相比，HER-2+ 肿瘤中 ER 和 PR 表达显着降低（ER，49.1% vs 78.17%；PR，24.3% vs 53.13%）。即使在HER-2+肿瘤中，高级别肿瘤中ER或PR表达率也比中级别肿瘤显着降低。 HER-2 在 10.87% 的 2 级导管癌和 27.84% 的 3 级导管癌中呈阳性，在所有 1 级导管癌中呈阴性。 HER-2 过度表达或扩增基本上仅限于 2 级和 3 级导管癌，并且与 ER 或 PR 表达呈负相关。尽管 HER-2+ 肿瘤中 ER 或 PR 表达降低，但其中很大一部分仍然表达 ER 或 PR。
We studied the inverse relationship between HER-2 and estrogen (ER) and progesterone (PR) receptors using HER-2 testing and correlated HER-2 status with histologic features in 3,655 unselected invasive breast carcinomas. Immunohistochemical analysis for ER, PR, and HER-2 and fluorescence in situ hybridization for HER-2 were performed. ER and PR expression were decreased significantly in HER-2+ tumors compared with HER-2-tumors (ER, 49.1 % vs 78.17%; PR, 24.3% vs 53.13%). Even among HER-2+ tumors, the rate of ER or PR expression in high-grade tumors was significantly decreased compared with intermediate-grade tumors. HER-2 was positive in 10.87% of grade 2 and 27.84% of grade 3 ductal carcinomas and negative in all grade 1 ductal carcinomas. HER-2 overexpression or amplification essentially was limited to grades 2 and 3 ductal carcinomas and correlated inversely with ER or PR expression. Although ER or PR expression is decreased in HER-2+ tumors, a substantial proportion of them still express ER or PR.